Inflammation insidan kinden
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Immune-mediated inflammatory diseases (IMIDs) in children: key research questions and some answers
- Editorial
- Open access
- Published:
Molecular and Cellular Pediatricsvolume 11, Article number: 5 () Cite this article
In children and adolescents, immune-mediated inflammatory diseases (IMIDs) constitute a large spectrum of chronic disorders characterized by complex pathophysiology, substantial disease burden, and often a lack of specific therapies.
In pediatric IMIDs, the inflammation is driven by on-going immunological mechanisms that constantly disrupt immune homeostasis favoring proinflammatory processes (e.g. proinflammatory cytokines, activated T cells and macrophages) while weakening regulatory signals (e.g. interleukin, regulatory T and B cells) [1]. Clinically, this leads to acute inflammatory symptoms across various organs and eventually progressive tissue damage and organ dysfunction. Depending on the predominantly affected organs and the extent of systemic inflammation, quality of life and the social participation can be significantly impaired and long-term sequelae including hypertension, dyslipidemia, cardiovascular diseases, chronic kidney disease, ca
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Paediatric Inflammation, Metabolism and Child Health Research
In the Group of Pediatric Inflammation research we study a number of common conditions such as asthma and allergies , intestinal inflammatory diseases and rheumatologic diseases. All of these disorders are characterized bygd inflammation.
Inflammatory markers such as exhaled nitric oxide are studied in order to find better tools for the diagnosis and monitoring of asthma and other conditions. Other markers are studies in relation to intestinal and/or rehmatic diseases. Cystic fibrosis, a rare disease that affects the lungs and exocrine secretions, leading to severe respiratory infections. The underlying cause is defective function of the chloride channel in the fängelse membrane. The research group is looking into better methods of treatment and diagnosis of this previously uniformly fatal condition. Researchers involved in the urinary tract are also members of the group. We study urinary tract infections and children with severe enuresis (bedwetting).
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Inflammation is a critical part of an immune system’s response to invaders and threats; it enables our bodies to attack infections and heal the damage they cause. Inflammation can also be triggered by other experiences, such as witnessing traumatic events or undergoing stressful circumstances, and this response helps our bodies to react to and survive those experiences.
However, if our bodies experience constant stress, this can lead to too much inflammation. If our organs are constantly in contact with inflammatory substances, those organs can be damaged over time. If those organ systems are still developing, as they are in early childhood, the state of constant activation can cause them to adapt in ways that have impacts across the lifespan. This is how chronic inflammation can put us at greater risk for things like cardiovascular disease, diabetes, asthma, and even depression and dementia.
Chronic inflammation may also create greater risk for those who become infected with COVID Many of the conditions that make it more difficult for a body to fight off COVID (such as heart disease, diabetes, and asthma) are related to chronic inflammation, which can be traced to